AMG 579

• Description:

  AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM.

• UNSPSC:

  12352005

• Target:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/AMG_579.html

• Concentration:

  10mM

• Purity:

  99.02

• Solubility:

  DMSO : 41.67 mg/mL (ultrasonic)

• Smiles:

  CC(N1CCC(C2=NC=CN=C2OC3=CC=C(C(C4=NC5=CC=CC=C5N4)=O)C=C3)CC1)=O

• Molecular Formula:

  C25H23N5O3

• Molecular Weight:

  441.48

• References & Citations:

  [1]Hu E, et al. Discovery of clinical candidate 1- (4- (3- (4- (1H-benzo[d]imidazole-2-carbonyl) phenoxy) pyrazin-2-yl) piperidin-1-yl) ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) . J Med Chem. 2014 Aug 14;57 (15) :6632-41.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  PDE10

• CAS Number:

  [1227067-61-9]