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DMT-dC (ac) Phosphoramidite

CAT: 0804-HY-138586-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-138586-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DMT-dC (ac) Phosphoramidite (compound 30f) is a phosphoramidite derivative that can be used for the oligonucleotide synthesis[1].
CAS Number
154110-40-4
UNSPSC
12352005
Hazard Statement
H315, H319
Target
DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dmt-dc-ac-phosphoramidite.html
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@@H]3[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C[C@H](N4C=CC(NC(C)=O)=NC4=O)O3)C5=CC=CC=C5)C=C1
Molecular Formula
C41H50N5O8P
Molecular Weight
771.84
Precautions
H315, H319
References & Citations
[1]Chillar K, et al. Oligonucleotide synthesis under mild deprotection conditions. New J Chem. 2023 May 14;47 (18) :8714-8722.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

Chemical Information

Ac-dC Phosphoramidite
CAS Number154110-40-4
PubChem CID70700205
IUPAC NameN-[1-[(2S,4R,5S)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide
Molecular FormulaC41H50N5O8P
Molecular Weight771.8
XLogP5.1
Topological Polar Surface Area144
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count18
Heavy Atom Count55
Formal Charge0
Complexity1320
SMILES
CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1C[C@H](O[C@H]1COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC)N5C=CC(=NC5=O)NC(=O)C
InChI
InChI=1S/C41H50N5O8P/c1-28(2)46(29(3)4)55(52-25-11-23-42)54-36-26-39(45-24-22-38(43-30(5)47)44-40(45)48)53-37(36)27-51-41(31-12-9-8-10-13-31,32-14-18-34(49-6)19-15-32)33-16-20-35(50-7)21-17-33/h8-10,12-22,24,28-29,36-37,39H,11,25-27H2,1-7H3,(H,43,44,47,48)/t36-,37+,39+,55?/m1/s1
InChIKey
MECWEBCHRKVTNV-QQIWIMIASA-N
Chemical Structure
2D Structure
2D structure of Ac-dC Phosphoramidite
CAS: 154110-40-4
CID: 70700205
Formula: C41H50N5O8P
MW: 771.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight771.8
XLogP35.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count18
Exact Mass771.33970057
Monoisotopic Mass771.33970057
Topological Polar Surface Area144 Ų
Heavy Atom Count55
Formal Charge0
Complexity1320
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
T36753DMT-dC (ac) Phosphoramidite
MBS5797821DMT-dC(ac) Phosphoramidite
D8620-01DMT-dC (Ac) -CE-Phosphoramidite
D9020-01DMT-2'-F-dC (Ac) -CE-Phosphoramidite
M-1005-2DC (Ac) -CE phosphoramidite
PA006-10DMTr-dC (Ac) -3'-CE-Phosphoramidite
447590-01DMT-2′O-TBDMS-rC (ac) Phosphoramidite
UYB08987-01DMT-2′O-TC-rC (ac) Phosphoramidite
D6160-01DMT-G (Ac) - (S) -GNA-CE-Phosphoramidite
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