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Cytochalasin A

CAT: 0804-HY-N6773-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6773-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives[1][2].
CAS Number
14110-64-6
UNSPSC
12352005
Hazard Statement
H300, H310, H330, H361
Target
Fungal; HIV Protease
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cytochalasin-a.html
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H]([C@@]([C@@]12[C@](/C=C/C[C@H](C)CCCC(/C=C/C(O1)=O)=O)([H])[C@@H]3O)([H])[C@@H](NC2=O)CC4=CC=CC=C4)C3=C
Molecular Formula
C29H35NO5
Molecular Weight
477.59
Precautions
H300, H310, H330, H361
References & Citations
[1]Kerman K, et al. An electrochemical approach for the detection of HIV-1 protease. Chem Commun (Camb) . 2007 Oct 7; (37) :3829-31.|[2]Antonio Bottalico, et al. Cytochalasins: Structure-activity relationships. Phytochemistry Volume 29, Issue 1, 1990.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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