Cytochalasin A

• Description :

  Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H300, H310, H330, H361

• Target :

  Fungal; HIV Protease

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/cytochalasin-a.html

• Purity :

  99.61

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C[C@@H]([C@@]([C@@]12[C@](/C=C/C[C@H](C)CCCC(/C=C/C(O1)=O)=O)([H])[C@@H]3O)([H])[C@@H](NC2=O)CC4=CC=CC=C4)C3=C

• Molecular Formula :

  C29H35NO5

• Molecular Weight :

  477.59

• Precautions :

  H300, H310, H330, H361

• References & Citations :

  [1]Kerman K, et al. An electrochemical approach for the detection of HIV-1 protease. Chem Commun (Camb) . 2007 Oct 7; (37) :3829-31.|[2]Antonio Bottalico, et al. Cytochalasins: Structure-activity relationships. Phytochemistry Volume 29, Issue 1, 1990.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [14110-64-6]