Cytochalasin A

• Target:

  Antifungal|||HIV Protease

• Related Pathways:

  Proteases/Proteasome|||Microbiology/Virology

• Bioactivity:

  Cytochalasin A, a cell-permeable fungal toxin and oxidized derivative of cytochalasin B, is an inhibitor of HIV-1 protease (IC50 = 3 ?M) . It inhibits actin polymerization, interferes with microtubule assembly by reacting with sulfhydryl groups, and serves as an antibiotic and bactericidal active agent.

• Smiles:

  [H][C@]12[C@H] (Cc3ccccc3) NC (=O) C11OC (=O) \C=C\C (=O) CCC[C@@H] (C) C\C=C\C1[C@H] (O) C (=C) [C@H]2C

• Molecular Formula:

  C29H35NO5

• Molecular Weight:

  477.59

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  14110-64-6