Cytochalasin A

• Target:

  Antifungal|||HIV Protease

• Related Pathways:

  Proteases/Proteasome|||Microbiology/Virology

• Bioactivity:

  Cytochalasin A, a cell-permeable fungal toxin and oxidized derivative of cytochalasin B, is an inhibitor of HIV-1 protease (IC50 = 3 ?M) . It inhibits actin polymerization, interferes with microtubule assembly by reacting with sulfhydryl groups, and serves as an antibiotic and bactericidal active agent.

• Smiles:

  [H][C@]12[C@H](Cc3ccccc3)NC(=O)C11OC(=O)\C=C\C(=O)CCC[C@@H](C)C\C=C\C1[C@H](O)C(=C)[C@H]2C

• Molecular Formula:

  C29H35NO5

• Molecular Weight:

  477.59

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  14110-64-6