D-Allose

• Description:

  D-Allose exhibits antitumor activity against various cancer cells. D-Allose scavenges reactive oxygen species (ROS) and reduces oxidative stress damage. D-Allose exhibits anti-inflammatory and neuroprotective through inhibition of TLR4/PI3K/AKT signaling pathway. D-Allose exhibits antihypertensive, cryoprotective, and anti-osteoporotic activities[1][2][5].

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H335

• Target:

  Akt; Apoptosis; Endogenous Metabolite; PI3K; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/d-allose.html

• Purity:

  99.85

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=C[C@@H]([C@@H]([C@@H]([C@@H](CO)O)O)O)O

• Molecular Formula:

  C6H12O6

• Molecular Weight:

  180.16

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Chen Z, et al., Recent research on the physiological functions, applications, and biotechnological production of D-allose. Appl Microbiol Biotechnol. 2018 May;102 (10) :4269-4278. |[2]Sui L, et al., Growth inhibitory effect of D-allose on human ovarian carcinoma cells in vitro. Anticancer Res. 2005 Jul-Aug;25 (4) :2639-44.|[3]Gao D, et al., Anti-inflammatory effect of D-allose in cerebral ischemia/reperfusion injury in rats. Neurol Med Chir (Tokyo) . 2013;53 (6) :365-74.|[4]Akumwami S, et al., Effects of D-Allose on experimental cardiac hypertrophy. J Pharmacol Sci. 2024 Oct;156 (2) :142-148.|[5]Luo Y, et al., D-allose Inhibits TLR4/PI3K/AKT Signaling to Attenuate Neuroinflammation and Neuronal Apoptosis by Inhibiting Gal-3 Following Ischemic Stroke. Biol Proced Online. 2023 Nov 28;25 (1) :30.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [2595-97-3]