BAPTA-AM

• Description :

  BAPTA-AM is a well-known membrane permeable Ca2+ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively[1].

• UNSPSC :

  12352200

• Hazard Statement :

  H315, H319, H335

• Target :

  Potassium Channel

• Type :

  Biochemical Assay Reagents

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/BAPTA-AM.html

• Purity :

  99.80

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(OCOC(C)=O)CN(C(C=CC=C1)=C1OCCOC(C=CC=C2)=C2N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O

• Molecular Formula :

  C34H40N2O18

• Molecular Weight :

  764.68

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Wie MB, et al. BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. Prog Neuropsychopharmacol Biol Psychiatry. 2001 Nov;25 (8) :1641-59.|[2]Tang Q, et al. The membrane permeable calcium chelator BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells. Biochem Pharmacol. 2007 Dec 3;74 (11) :1596-607.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Biochemical Assay Reagents

• Clinical Information :

  No Development Reported

• CAS Number :

  [126150-97-8]