BAPTA (tetrasodium)

• Description:

  BAPTA tetrasodium is a selective chelator for calcium. BAPTA tetrasodium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrasodium is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA tetrasodium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Phospholipase

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Purity:

  99.70

• Solubility:

  H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(O[Na])CN(C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(O[Na])=O)CC(O[Na])=O)CC(O[Na])=O

• Molecular Formula:

  C22H20N2Na4O10

• Molecular Weight:

  564.36

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]R Y Tsien, et al. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 1980 May 27;19 (11) :2396-404. |[2]Roger C Hardie, et al. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis (2-aminophenoxy) ethane N, N, N', N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium. 2005 Dec;38 (6) :547-56. |[3]M B Collatz, et al. Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [126824-24-6]