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Sotorasib

CAT: 0421-82712-3Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0421-82712-3Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
It is well established that RAS mutations are responsible for more than 30% of human cancers. KRAS (G12C) is the most frequent mutation, found in lung and colon carcinomas. Recent studies uncovered a small molecule called AMG510 (Amgen), or Sotorasib, that inhibits the KRAS (G12C) -mediated signaling pathway by locking the KRAS conformation in the GDP-bound state. Compounds that block the nucleotide exchange (GDP to GTP) reaction in KRAS could lead to the inhibition of tumor cell proliferation in KRAS (G12C) -driven tumors.
Description
Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors1,2.
CAS Number
2296729-00-3
Purity
≥ 90%
Format
Powder.
Solubility
Soluble in DMSO up to 50 mg/mL. In H20, up to 33.33 mg/mL.
Molecular Formula
C30H30F2N6O3
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, stored under nitrogenIn solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Calculated Molecular Weight
560.59 Da

Alternative Products

CatalogName
M21832-01Sotorasib
C13702-01Sotorasib (AMG510)
CS-O-46271Sotorasib D3
CS-O-53097Sotorasib-d7
GTR19264820-01Sotorasib isomer
AR-S09572-01Sotorasib-d3
HY-114277R-01Sotorasib (Standard)
HY-114277A-01Sotorasib (racemate)

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