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2′-Hydroxy-5′-methoxyacetophenone

CAT: 0804-HY-N1731-01Size: 10 gDry Ice: NoHazardous: No
CAT#:0804-HY-N1731-01Size:10 g
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2'-Hydroxy-5'-methoxyacetophenone is an acetophenone derivative with acaricidal activities. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inflammatory response via NF-κB signaling pathway. 2'-Hydroxy-5'-methoxyacetophenone exhibits significant inhibitory activity against α-amylase, collagenase and aldose reductase (AR) with IC50s of 0.928, 3.264 and 20.046 μM, highlighting its potential in combating diabetes. 2'-Hydroxy-5'-methoxyacetophenone exhibits anti-ovarian cancer activity[1][2][3].
CAS Number
[705-15-7]
UNSPSC
12352200
Hazard Statement
H315, H318, H335
Target
COX; NF-κB; NO Synthase; Parasite; Reactive Oxygen Species (ROS) ; TNF Receptor
Type
Biochemical Assay Reagents
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2-hydroxy-5-methoxyacetophenone.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C1=CC(OC)=CC=C1O)=O
Molecular Formula
C9H10O3
Molecular Weight
166.18
Precautions
H315, H318, H335
References & Citations
[1]Zhou J, et al. Discovery of 2-Ethoxy-5-isobutyramido-N-1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects. J Med Chem. 2024 Jan 11;67 (1) :213-233. |[2]Kim MG, Yang JY, Lee HS. Acaricidal potentials of active properties isolated from Cynanchum paniculatum and acaricidal changes by introducing functional radicals. J Agric Food Chem. 2013 Aug 7;61 (31) :7568-73.|[3]Li Wang et, al. Anti-ovarian cancer and collagenase, alpha amylase, and aldose reductase inhibition properties of 2′-Hydroxy-5′-methoxyacetophenone with molecular modeling studies. 2021 Sep.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Isoform
COX-2; iNOS; NF-κB

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