2′-Hydroxy-5′-methoxyacetophenone

• Description :

  2'-Hydroxy-5'-methoxyacetophenone is an acetophenone derivative with acaricidal activities. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inflammatory response via NF-κB signaling pathway. 2'-Hydroxy-5'-methoxyacetophenone exhibits significant inhibitory activity against α-amylase, collagenase and aldose reductase (AR) with IC50s of 0.928, 3.264 and 20.046 μM, highlighting its potential in combating diabetes. 2'-Hydroxy-5'-methoxyacetophenone exhibits anti-ovarian cancer activity[1][2][3].

• UNSPSC :

  12352200

• Hazard Statement :

  H315, H318, H335

• Target :

  COX; NF-κB; NO Synthase; Parasite; Reactive Oxygen Species (ROS) ; TNF Receptor

• Type :

  Biochemical Assay Reagents

• Related Pathways :

  Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research :

  Cancer; Infection; Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/2-hydroxy-5-methoxyacetophenone.html

• Purity :

  99.96

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(C1=CC(OC)=CC=C1O)=O

• Molecular Formula :

  C9H10O3

• Molecular Weight :

  166.18

• Precautions :

  H315, H318, H335

• References & Citations :

  [1]Zhou J, et al. Discovery of 2-Ethoxy-5-isobutyramido-N-1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects. J Med Chem. 2024 Jan 11;67 (1) :213-233. |[2]Kim MG, Yang JY, Lee HS. Acaricidal potentials of active properties isolated from Cynanchum paniculatum and acaricidal changes by introducing functional radicals. J Agric Food Chem. 2013 Aug 7;61 (31) :7568-73.|[3]Li Wang et, al. Anti-ovarian cancer and collagenase, alpha amylase, and aldose reductase inhibition properties of 2′-Hydroxy-5′-methoxyacetophenone with molecular modeling studies. 2021 Sep.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Biochemical Assay Reagents

• Clinical Information :

  No Development Reported

• Isoform :

  COX-2; iNOS; NF-κB

• CAS Number :

  [705-15-7]