NMB-1

• Description:

  NMB-1 (Noxious mechanosensation blocker 1) is an analogue of a peptide isolated from a marine conesnail. This 19 amino acid peptide has shown a 30 fold selectivity in inhibiting slowly adapting mechanically activated currents over rapidly adapting ones. It is an interesting tool to distinguish between RA and SA currents. NMB-1 significantly blocks SA currents at 1 µM in sensory neurons contrary to GsMTx4. Some results suggest that NMB-1 could also block mechanosensitive ion channels in cochlear hair cells at 5 µM. Smartox Biotechnology is pleased to be the first company offering this research tool.

• Specifications:

  SA currents blocker

• Target:

  Mechanosensitive channels

• Sequence:

  FNWRCCLIPCRRNHKKFFC

• Peptide Number:

  NMB001

• Disulfide Bonds:

  Cys5-Cys19; Cys6-Cys10

• N Terminal Sequence:

  H

• C Terminal Sequence:

  OH