GsAF-1

• Description:

  GsAF-1 (also termed β-theraphotoxin-Gr1b, GsAF-I) was originally isolated from the venom of Grammostola rosea spider. GsAF-I peptide toxin is reported to block the following voltage-gated sodium channel isoforms: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with respective IC50 values of 0.4,0.6,1.3,0.3,1.2 and 0.04 µM. In addition, the toxin blocks the hERG1 isoform with an IC50 value of 4.8 µM.

• Specifications:

  Voltage-gated sodium channels blocker

• Target:

  Na channels

• Sequence:

  YCQKWLWTCDSERKCCEDMVCRLWCKKRL

• Peptide Number:

  12GSF001

• Disulfide Bonds:

  Cys2-Cys16; Cys9-Cys21; ; Cys15-Cys25

• N Terminal Sequence:

  H

• C Terminal Sequence:

  NH2