GsAF-2

CAT: 0466-12GSF002-01000Size: 1 mgDry Ice: NoHazardous: No
CAT#:0466-12GSF002-01000Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
GsAF-II (also termed Kappa-theraphotoxin-Gr2c, GsAF-2) was originally isolated from the venom of Grammostola rosea spider. GsAF-II peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with IC50 values of, respectively, 5.7,12,24,4, 6.6 and 1.3 µM. This peptide also blocks hERG1 with an IC50 value of 4.7 µM.
Specifications
Blocker of Nav1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7
Target
Na channels
Sequence
YCQKWMWTCDEERKCCEGLVCRLWCKKKIEW
Peptide Number
12GSF002
Disulfide Bonds
Cys2-Cys16; Cys9-Cys21; ; Cys15-Cys25
N Terminal Sequence
H
C Terminal Sequence
OH

Related Products

CatalogName
12GSF001GsAF-1
12GSF001-00500GsAF-1
12GSF001-01000GsAF-1
12GSF001-00100GsAF-1
PHX002-50010Phrixotoxin-2
13AGI002-01000Agitoxin-2
PHX002-00100Phrixotoxin-2
13AGI002-00500Agitoxin-2
PHX002-01000Phrixotoxin-2
13AGI002Agitoxin-2

Alternative Products

CatalogName
HY-P5167GsAF-1
MF-0157991-01GsAF-I
HY-P5177GsAF-II
PC1003049-012,2,2-Trifluoroethyl 2,2,2-trichloroacetate
H 038-0012'- , 2''-, 2''', 2'''', 2''''', 2''''''- Hexadeoxy- 2'-, 2'', 2''', 2'''', 2''''', 2''''''- hexafluoro- cyclic hexaadenosine monophosphate (2',2'',2''',2'''',2''''',2''''''-Hexa-F-c-hexadAMP / cFA6), sodium salt
PC32719-012,2,2,2'-Tetrafluoroacetophenone
OR1009873-012,2,2,2-Ethylenedinitrilotetraethanol
MBS6024187-012,2,2-Trifluoroethyl 2,5-Bis(2,2,2-trifluoroethoxy)benzoate
0222612,2,2-Trifluoroethyl 2-Hydroxy-5- (2,2,2-trifluoroethoxy) benzoate
sc-2092832,2,2-Trifluoroethyl 2,5-Bis (2,2,2-trifluoroethoxy) benzoate

Popular Products