Agitoxin-2

• Description:

  Agitoxin-2 is a potent and selective blocker of the Shaker type voltage-gated Kv1.3 and Kv1.1 channels. Agitoxin-2 inhibits Kv1.3 with an IC50 value of around 200 pM and Kv1.1 with an IC50 value of around 140 pM. This peptide toxin was originally isolated from the venom of the Israeli scorpion L. quinquestriatus hebraeus.

• Specifications:

  Blocker of Kv1.1 and Kv1.3 channels

• CAS Number:

  168147-41-9

• Target:

  K channels

• Sequence:

  GVPINVSCTGSPQCIKPCKDAGMRFGKCMNRKCHCTPK

• Peptide Number:

  13AGI002

• Disulfide Bonds:

  Cys8-Cys28; Cys14-Cys33; Cys18-Cys35

• N Terminal Sequence:

  H

• C Terminal Sequence:

  OH