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GaTx2

CAT: 0466-10GTX002-00500Size: 0.5 mgDry Ice: NoHazardous: No
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CAT#:0466-10GTX002-00500Size:0.5 mg
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Description
GaTx2 (gating modifier of anion channels 2) was isolated from the venom of Leiurus quinquestriatus hebraeus. GaTx2 is the most potent peptide inhibitor of ClC-2 (CLCN2) chloride channel ever described. Kd value is close to 20 pM. GaTx2slows ClC-2 activation but without altering channel conductance. The effect is voltage-dependent. This inhibitory effect was highlighted on rabbit ClC-2 channels expressed in oocytes. It has no effect on ClC-0, ClC-1, ClC-3, ClC-4, CFTR, GABAC, Xenopus ClCa, Shaker B or Kv1.2 channels. Structurally, GaTx2 is composed of two β-strands and one α-helix.This peptide is also called Leiuropeptide II. Bears 89,93 and 96% identity with OdK1, neurotoxin PO1 and leiuropeptide III, respectively.
Specifications
Selective blocker of ClC2 (CLCN2) chloride channels
Target
Cl channels
Sequence
VSCEDCPDHCSTQKARAKCDNDKCVCEPI
Peptide Number
10GTX002
Disulfide Bonds
Cys3-Cys19; Cys6-Cys24; ; Cys10-Cys26
N Terminal Sequence
H
C Terminal Sequence
OH

Alternative Products

CatalogName
B5761-.1GaTx2
MBS1053253-01Recombinant Leiurus quinquestriatus hebraeus Toxin GaTx2

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