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GaTx2

CAT: 0804-HY-P1105Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1105Size:100 µg
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Description
GaTx2 is a seletive and a high affinity inhibitor of ClC-2 channels with a voltage-dependent apparent KD of ∼20 pM. GaTx2 is a peptide toxin inhibitor from Leiurus quinquestriatus hebraeus venom. GaTx2 is useful in determining the role and the membrane localization of ClC-2 in specific cell types[1].
CAS Number
194665-85-5
UNSPSC
12352209
Target
Chloride Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gatx2.html
Purity
98.00
Solubility
10 mM in DMSO
Smiles
O=C1N2[C@](CCC2)([H])C(N[C@H](C(N[C@H](C(N[C@]3([H])C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@]4([H])CSSCC(C(NC(C(NC(C(N[C@@]1([H])CSSC[C@](C(N[C@H](C(N[C@@H](CSSC3)C(N[C@@H](CCC(O)=O)C(N5[C@@H](CCC5)C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O)=O)=O)C(C)C)=O)([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC4=O)CC(O)=O)=O)CC(N)=O)=O)CC(O)=O)=O)CCCCN)=O)=O)CC(O)=O)=O)CCC(O)=O)=O)NC([C@H](CO)NC([C@@H](N)C(C)C)=O)=O)=O)CCCCN)=O)C)=O)CCCNC(N)=N)=O)C)=O)CCCCN)=O)CCC(N)=O)=O)([H])[C@H](O)C)=O)CO)=O)=O)CC6=CN=CN6)=O)CC(O)=O)=O
Molecular Formula
C125H199N39O47S6
Molecular Weight
3192.54
References & Citations
[1]Christopher H Thompson, et al. Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels.J Biol Chem
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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