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GaTx2

CAT: 0931-TP2027Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP2027Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
194665-85-5
Target
Chloride channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
Very high affinity ClC-2 blocker (apparent KD ~ 50 pM) . Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.
Smiles
O=C1N2[C@](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N[C@@]4(C(=O)N[C@@H](CO)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@]5(CSSC[C@H](NC([C@@H](NC([C@H](C(C)C)N)=O)CO)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@]1(CSSC[C@](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC5=O)(C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(N[C@H](C(=O)N6[C@H](C(N[C@@H]([C@H](CC)C)C(O)=O)=O)CCC6)CCC(O)=O)=O)CSSC4)[H])[H])[H])[H])[H])(CCC2)[H]
Molecular Formula
C125H199N39O47S6
Molecular Weight
3192.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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