AAT-008

CAT: 0804-HY-122168-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-122168-01Size:5 mg
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Description
AAT-008 is a potent, selective, and orally active prostaglandin EP4 receptor antagonist with Kis of 0.97 and 6.1 nM for recombinant human EP4 and recombinant rat EP4, respectively. AAT-008 exerts tumor growth delay in mice bearing CT26WT colon tumors when combined with radiotherapy. AAT-008 can be used for the study of acute and chronic inflammatory pain and cancer [1][2].
CAS Number
[847727-81-5]
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/aat-008.html
Concentration
10mM
Purity
98.55
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C([C@@H](NC(C2=CC(Cl)=CN=C2OC3=CC=CC(F)=C3)=O)C)C=C1
Molecular Formula
C21H16ClFN2O4
Molecular Weight
414.81
References & Citations
[1]Okumura Y, et al. Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist. Bioorg Med Chem Lett. 2017;27 (5) :1186-1192. |[2]Manabe Y, et al. Biological effects of prostaglandin E2-EP4 antagonist (AAT-008) in murine colon cancer in vivo: enhancement of immune response to radiotherapy and potential as a radiosensitizer. Transl Cancer Res. 2023 Feb 28;12 (2) :351-358.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP

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