TP-008

• Description:

  TP-008, a chemical probe, is a potent, selective and orally active (Activin-Like Kinase 5) ALK5 inhibitor with pIC50 and pEC50 values of 7.6 and 6.63, respectively. TGFβRI-IN-2 can produce observed cardiac toxicity in vivo at high dose[1].

• UNSPSC:

  12352005

• Target:

  TGF-β Receptor

• Type:

  Reference compound

• Related Pathways:

  TGF-beta/Smad

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/tgfβri-in-2.html

• Concentration:

  10mM

• Purity:

  99.42

• Solubility:

  DMSO : 9.6 mg/mL (ultrasonic; warming)

• Smiles:

  O=C (N) CN (C1=C2C=CN=C1) C (N2C3=CC (C4=CC (Cl) =CC=C4F) =NC=C3C) =O

• Molecular Formula:

  C20H15ClFN5O2

• Molecular Weight:

  411.82

• References & Citations:

  [1]Wang H, et al. Design, synthesis and optimization of novel Alk5 (activin-like kinase 5) inhibitors.Bioorg Med Chem Lett. 2016 Sep 1;26 (17) :4334-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1976038-41-1