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ADS032

CAT: 0804-HY-156798-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-156798-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ADS032 is a sulfonylurea compound that is an NLRP1 and NLRP3 inflammasome inhibitor. ADS032 reduces the secretion of inflammatory factors and inhibits the oligomerization of ASC. ADS032 has anti-inflammatory effects in a variety of inflammatory models and can be used in the study of inflammatory diseases[1].
CAS Number
2757333-37-0
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ads032.html
Concentration
10mM
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(CCCC1=CC=C(C2=CC=C(S(=O)(N(CCC)CCC)=O)C=C2)C=C1)O
Molecular Formula
C22H29NO4S
Molecular Weight
403.53
References & Citations
[1]Docherty CA, et al. A novel dual NLRP1 and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases. Clin Transl Immunology. 2023 Jun 22;12 (6) :e1455.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP1; NLRP3

Chemical Information

4-[4-[4-(Dipropylsulfamoyl)phenyl]phenyl]butanoic acid
CAS Number2757333-37-0
PubChem CID162429727
IUPAC Name4-[4-[4-(dipropylsulfamoyl)phenyl]phenyl]butanoic acid
Molecular FormulaC22H29NO4S
Molecular Weight403.5
XLogP4.6
Topological Polar Surface Area83.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count11
Heavy Atom Count28
Formal Charge0
Complexity550
SMILES
CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)CCCC(=O)O
InChI
InChI=1S/C22H29NO4S/c1-3-16-23(17-4-2)28(26,27)21-14-12-20(13-15-21)19-10-8-18(9-11-19)6-5-7-22(24)25/h8-15H,3-7,16-17H2,1-2H3,(H,24,25)
InChIKey
UNMDICXGCNPMPK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-[4-[4-(Dipropylsulfamoyl)phenyl]phenyl]butanoic acid
CAS: 2757333-37-0
CID: 162429727
Formula: C22H29NO4S
MW: 403.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight403.5
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count11
Exact Mass403.18172958
Monoisotopic Mass403.18172958
Topological Polar Surface Area83.1 Ų
Heavy Atom Count28
Formal Charge0
Complexity550
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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