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ADS032

CAT: 0804-HY-156798-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-156798-01Size:5 mg
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Description
ADS032 is a sulfonylurea compound that is an NLRP1 and NLRP3 inflammasome inhibitor. ADS032 reduces the secretion of inflammatory factors and inhibits the oligomerization of ASC. ADS032 has anti-inflammatory effects in a variety of inflammatory models and can be used in the study of inflammatory diseases[1].
CAS Number
[2757333-37-0]
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ads032.html
Concentration
10mM
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(CCCC1=CC=C(C2=CC=C(S(=O)(N(CCC)CCC)=O)C=C2)C=C1)O
Molecular Formula
C22H29NO4S
Molecular Weight
403.53
References & Citations
[1]Docherty CA, et al. A novel dual NLRP1 and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases. Clin Transl Immunology. 2023 Jun 22;12 (6) :e1455.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP1; NLRP3

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