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SHOX2 rabbit pAb

CAT: 0855-ES13119-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES13119-01Size:50 µL
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Background
This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Description
This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009],
UniProt
O60902
Swiss Prot
O60902
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human SHOX2 AA range: 37-87
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; FCM
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300, FCM 1:100-200
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus.
Gene ID (Human)
6474

UniProtKB · O60902

Short stature homeobox protein 2

SHOX2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O60902
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SHOX2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
O60465, O60467, O60903
Protein keywords

Coding sequence diversity

Alternative splicing

Molecular function

Developmental proteinDNA-binding

Domain

Homeobox

Cellular component

Nucleus

Technical term

Proteomics identificationReference proteome

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