Cridanimod

CAT: 0804-HY-W011890-08Size: 5 gDry Ice: NoHazardous: No

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CAT#:0804-HY-W011890-08Size:5 g

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Description

Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer[1][2].

CAS Number

38609-97-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IFNAR; Progesterone Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/cridanimod.html

Purity

99.97

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)CN(C1=C2C=CC=C1)C3=CC=CC=C3C2=O

Molecular Formula

C15H11NO3

Molecular Weight

253.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Xenetic Biosciences Announces FDA Acceptance of Investigational New Drug Application to Initiate Phase 2 Clinical Trial of Virexxa® in Endometrial Cancer. AUGUST 19, 2016|[2]Matthew J. Carlson, et al. Cridanimod and progestin therapy in hormone-resistant endometrial cancer. Journal of Clinical Oncology, January 30, 2017.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Chemical Information

Cridanimod

Cridanimod is a member of acridines. It is functionally related to an acridone.

CAS Number	38609-97-1
PubChem CID	38072
IUPAC Name	2-(9-oxoacridin-10-yl)acetic acid
Molecular Formula	C15H11NO3
Molecular Weight	253.25
XLogP	2.7
Topological Polar Surface Area	57.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Heavy Atom Count	19
Formal Charge	0
Complexity	356

SMILES

C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3N2CC(=O)O

InChI

InChI=1S/C15H11NO3/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16/h1-8H,9H2,(H,17,18)

InChIKey

UOMKBIIXHQIERR-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 38609-97-1

CID: 38072

Formula: C15H11NO3

MW: 253.25

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	253.25
XLogP3	2.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	253.07389321
Monoisotopic Mass	253.07389321
Topological Polar Surface Area	57.6 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	356
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
BA6005-5.1	Cridanimod
562223	Cridanimod sodium
MBS3605171-01	Sodium Cridanimod

Cridanimod

Chemical Information

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