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Cridanimod

CAT: 0804-HY-W011890-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W011890-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod is a small-molecule immunomodulator and interferon inducer[1][2].
CAS Number
38609-97-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IFNAR; Progesterone Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/cridanimod.html
Purity
99.97
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(O)CN(C1=C2C=CC=C1)C3=CC=CC=C3C2=O
Molecular Formula
C15H11NO3
Molecular Weight
253.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Xenetic Biosciences Announces FDA Acceptance of Investigational New Drug Application to Initiate Phase 2 Clinical Trial of Virexxa® in Endometrial Cancer. AUGUST 19, 2016|[2]Matthew J. Carlson, et al. Cridanimod and progestin therapy in hormone-resistant endometrial cancer. Journal of Clinical Oncology, January 30, 2017.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Chemical Information

Cridanimod

Cridanimod is a member of acridines. It is functionally related to an acridone.

CAS Number38609-97-1
PubChem CID38072
IUPAC Name2-(9-oxoacridin-10-yl)acetic acid
Molecular FormulaC15H11NO3
Molecular Weight253.25
XLogP2.7
Topological Polar Surface Area57.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count19
Formal Charge0
Complexity356
SMILES
C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3N2CC(=O)O
InChI
InChI=1S/C15H11NO3/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16/h1-8H,9H2,(H,17,18)
InChIKey
UOMKBIIXHQIERR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cridanimod
CAS: 38609-97-1
CID: 38072
Formula: C15H11NO3
MW: 253.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight253.25
XLogP32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass253.07389321
Monoisotopic Mass253.07389321
Topological Polar Surface Area57.6 Ų
Heavy Atom Count19
Formal Charge0
Complexity356
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

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BA6005-5.1Cridanimod
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MBS3605171-01Sodium Cridanimod

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