2’-Azido-2’-deoxycytidine

2’-Azido-2’-deoxycytidine

• CAS Number: 51034-68-5
• UNSPSC Description: 2’-Azido-2’-deoxycytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2’-Azido-2’-deoxycytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. 2’-Azido-2’-deoxycytidine is an azidonucleoside,and it should be phosphorylated twice to become an inhibitor of the nucleotide reductase.
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/2-azido-2-deoxycytidine.html
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: OC[C@@H]1[C@@H](O)[C@@H](N=[N+]=[N-])[C@H](N2C(N=C(N)C=C2)=O)O1
• Molecular Weight: 268.23
• References & Citations: [1]Kang SH, Cho MJ. Biological activity and phosphorylation of 2'-azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine. Nucleosides Nucleotides. 1998;17(6):1077-1088.|[2]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-3388.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported