AC-264613

• Description :

  AC-264613 is a potent and selective protease-activated receptor (PAR-2) agonist with a pEC50 of 7.5[1].

• CAS Number :

  [1051487-82-1]

• UNSPSC :

  12352005

• Target :

  Protease Activated Receptor (PAR)

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ac-264613.html

• Purity :

  98.3

• Solubility :

  10 mM in DMSO|DMSO : ≥ 40mg/mL

• Smiles :

  O=C(N/N=C(C1=CC=CC(Br)=C1)\C)[C@H]2[C@@H](CNC2=O)C3=CC=CC=C3

• Molecular Formula :

  C19H18BrN3O2

• Molecular Weight :

  400.27

• References & Citations :

  [1]Jimmi Gerner Seitzberg, et al. Discovery of potent and selective small-molecule PAR-2 agonists. J Med Chem. 2008 Sep 25;51 (18) :5490-3.|[2]Rui Yamaguchi, et al. A protease-activated receptor 2 agonist (AC-264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages: Role of p53. Cell Biol Int. 2016 Jun;40 (6) :629-41.|[3]Luis R Gardell, et al. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J Pharmacol Exp Ther. 2008 Dec;327 (3) :799-808.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported