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Hexadecanamide

CAT: 0804-HY-121389-02Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121389-02Size:250 mg
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Description
Hexadecanamide (Palmitamide) is a fatty acid amide that has orally active anti-allergic, antioxidant, and neuroprotective effects. Hexadecanamide exerts protective effects in Staphylococcus aureus- and SARA-induced mastitis. Hexadecanamide suppresses S. aureus-induced activation of the NF-κB pathway and improves blood-milk barrier integrity. Hexadecanamide activates PPARα. Hexadecanamide enhances sperm motility in vitro. Hexadecanamide can be studied in research for mastitis and asthenozoospermia[1][2].
CAS Number
629-54-9
Product Name Alternative
Palmitamide
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; NF-κB; PPAR
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hexadecanamide.html
Purity
97.0
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC(CCCCCCCCCCCCCCC)=O
Molecular Formula
C16H33NO
Molecular Weight
255.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Bao L, et al. Hexadecanamide alleviates Staphylococcus aureus-induced mastitis in mice by inhibiting inflammatory responses and restoring blood-milk barrier integrity. PLoS Pathog. 2023 Nov 10;19 (11) :e1011764.|[2]Han B, et al. Changes in seminal plasma microecological dynamics and the mechanistic impact of core metabolite hexadecanamide in asthenozoospermia patients. Imeta. 2024 Jan 25;3 (2) :e166. https://pubmed.ncbi.nlm.nih.gov/38882497/
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PPARα

Chemical Information

Hexadecanamide

Hexadecanamide is a fatty amide that is the carboxamide derived from palmitic acid. It has a role as a metabolite. It is functionally related to a hexadecanoic acid.

CAS Number629-54-9
PubChem CID69421
IUPAC Namehexadecanamide
Molecular FormulaC16H33NO
Molecular Weight255.44
XLogP5.7
Topological Polar Surface Area43.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count14
Heavy Atom Count18
Formal Charge0
Complexity180
SMILES
CCCCCCCCCCCCCCCC(=O)N
InChI
InChI=1S/C16H33NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H2,17,18)
InChIKey
HSEMFIZWXHQJAE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hexadecanamide
CAS: 629-54-9
CID: 69421
Formula: C16H33NO
MW: 255.44
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight255.44
XLogP35.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count14
Exact Mass255.256214676
Monoisotopic Mass255.256214676
Topological Polar Surface Area43.1 Ų
Heavy Atom Count18
Formal Charge0
Complexity180
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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