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MS159

CAT: 0804-HY-151101-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-151101-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MS159 is a potent nuclear receptor binding SET structural domain protein 2 (NSD2) PROTACdegrader. MS159 inhibits the growth of tumour cells. MS159 is a useful chemical tool for exploring the role of NSD2 in health and disease[1].
CAS Number
3031353-59-7
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms159.html
Purity
99.38
Solubility
DMSO : 100 mg/mL (ultrasonic; heat to 60°C)
Smiles
O=C(NCCCOC1=CN=C(C=C1)NC(C2=CC=C(C=C2)CN(C3CC3)C(C4=CC=C5NC(COC5=C4)=O)=O)=O)CNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O
Molecular Formula
C43H40N8O10
Molecular Weight
828.83
References & Citations
[1]Fanye Meng, et al. Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos. J Med Chem. 2022 Aug 11;65 (15) :10611-10625.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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