Products for Research Use Only
RegisterLogin

MS154

CAT: 0804-HY-141640-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-141640-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MS154 is a first-in-class E3 ligase cereblon-recruited EGFR degrader with Kd values of 1.8 nM and 3.8 nM for EGFR WT and EGFR L858R mutant, respectively. MS154 potently induces degradation of mutant, but not wild-type, EGFR in cancer cell lines in an E3 ligase-dependent manner. MS154 exhibits anticancer effects against lung cancer (blue: E3 ligase ligand ; black: linker (HY-W096167) ; pink: EGFR ligand (HY-168305) ).
CAS Number
2550393-21-8
UNSPSC
12352005
Target
EGFR; PROTACs
Type
Reference compound
Related Pathways
JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms154.html
Purity
99.71
Solubility
DMSO : 90.14 mg/mL (ultrasonic; warming)
Smiles
O=C1NC(C(CC1)N2C(C3=C(C2=O)C(OCCCCCCCCNC(CCN4CCN(CCCOC5=CC6=C(NC7=CC=C(C(Cl)=C7)F)N=CN=C6C=C5OC)CC4)=O)=CC=C3)=O)=O
Molecular Formula
C46H54ClFN8O8
Molecular Weight
901.42
References & Citations
[1]Meng Cheng, et al. Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders. J Med Chem. 2020 Feb 13;63 (3) :1216-1232.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; EGFR/ErbB1/HER1

Related Products

CatalogName
HY-151101-01MS159
HY-157579MS154N
HY-161759-01MS152
HY-151613-01MS15
HY-151613A-01MS15 (TFA)

Alternative Products

CatalogName
JH919692MS154

Popular Products