GCN2iB

• UNSPSC Description:

  GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM.

• Target Antigen:

  Autophagy; Eukaryotic Initiation Factor (eIF)

• Type:

  Reference compound

• Related Pathways:

  Autophagy;Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/GCN2iB.html

• Purity:

  99.90

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=S(C1=CC(Cl)=CN=C1OC)(NC2=CC=C(F)C(C#CC3=CN=C(N)N=C3)=C2F)=O

• Molecular Weight:

  451.83

• References & Citations:

  [1]Nakamura A, et al. Inhibition of GCN2 sensitizes ASNS-low cancer cells by disrupting the amino acid response. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7776-E7785.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2183470-12-2