GCN2iB

• Description :

  GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy; Eukaryotic Initiation Factor (eIF)

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Cell Cycle/DNA Damage

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/GCN2iB.html

• Concentration :

  10mM

• Purity :

  99.83

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=S(C1=CC(Cl)=CN=C1OC)(NC2=CC=C(F)C(C#CC3=CN=C(N)N=C3)=C2F)=O

• Molecular Formula :

  C18H12ClF2N5O3S

• Molecular Weight :

  451.83

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Nakamura A, et al. Inhibition of GCN2 sensitizes ASNS-low cancer cells by disrupting the amino acid response. Proc Natl Acad Sci U S A. 2018 Aug 14;115 (33) :E7776-E7785.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  EIF2

• CAS Number :

  [2183470-12-2]