RECQL5-IN-1

• UNSPSC Description:

  RECQL5-IN-1 (Compound 4a) acts as an orally effective RECQL5 inhibitor (targeting both enzymatic and nonenzymatic domain). RECQL5-IN-1 is a potent inhibitor of RECQL5 helicase activity (IC50=46.3 nM). RECQL5-IN-1 inhibits RECQL5-WT cells and RECQL5-KO2 cells with IC50s of 4.8 μM and 19.6 μM, respectively. RECQL5-IN-1 can be used for the research of breast cancer[1].

• Target Antigen:

  DNA/RNA Synthesis; Others

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/recql5-in-1.html

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  FC(F)(F)C1=CC(C(F)(F)F)=CC(NC(N[C@@H](C2=CC=CC=C2)C3=NN=C(SCC4=CC=CC=C4)O3)=O)=C1

• Molecular Weight:

  552.49

• References & Citations:

  [1]Saikat Chakraborty, et al. Targeting RECQL5 Functions, by a Small Molecule, Selectively Kills Breast Cancer in Vitr o and in Vivo. J Med Chem. 2021 Feb 11;64(3):1524-1544.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2718170-45-5