4,5-Dimethoxycanthin-6-one

• UNSPSC Description:

  4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae)[1][2].

• Target Antigen:

  Cytochrome P450

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/4-5-dimethoxycanthin-6-one.html

• Purity:

  98.68

• Solubility:

  DMSO : 10 mg/mL (ultrasonic)

• Smiles:

  O=C1N2C3=C(N=CC=C3C4=C2C=CC=C4)C(OC)=C1OC

• Molecular Weight:

  280.28

• References & Citations:

  [1]Taichi O, et al. Studies on the Constituents of Picrasma quassioides BENNET. III. The Alkaloidal Constituents|[2]Miao X,et al. In vitro metabolism of 4, 5-dimethoxycanthin-6-one by human liver microsomes and its inhibition on human CYP1A2. Life Sci. 2017;190:46-51.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  18110-87-7