4,5-Dimethoxycanthin-6-one
CAT:
804-HY-N1882-03
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
4,5-Dimethoxycanthin-6-one
- CAS Number: 18110-87-7
- UNSPSC Description: 4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae)[1][2].
- Target Antigen: Cytochrome P450
- Type: Natural Products
- Related Pathways: Metabolic Enzyme/Protease
- Applications: Metabolism-sugar/lipid metabolism
- Field of Research: Metabolic Disease
- Assay Protocol: https://www.medchemexpress.com/4-5-dimethoxycanthin-6-one.html
- Purity: 98.68
- Solubility: DMSO : 10 mg/mL (ultrasonic)
- Smiles: O=C1N2C3=C(N=CC=C3C4=C2C=CC=C4)C(OC)=C1OC
- Molecular Weight: 280.28
- References & Citations: [1]Taichi O, et al. Studies on the Constituents of Picrasma quassioides BENNET. III. The Alkaloidal Constituents|[2]Miao X,et al. In vitro metabolism of 4, 5-dimethoxycanthin-6-one by human liver microsomes and its inhibition on human CYP1A2. Life Sci. 2017;190:46-51.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, protect from light)
- Clinical Information: No Development Reported