CTP

• Description:

  CTP (cardiac targeting peptide) can transduce cardiomyocytes in vitro. CTP leads to efficient and specific transduction of heart tissue in mice model. CTP can be reversibly linked (e.g. via enolases, thiol groups) to cargo (e.g. miRNAs) for delivery specifically to cardiomyocytes over all other organs[1][2].

• Product Name Alternative:

  Cardiac targeting peptide

• UNSPSC:

  12352209

• Target:

  Others

• Type:

  Peptides

• Related Pathways:

  Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/ctp.html

• Purity:

  99.66

• Solubility:

  H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(N1[C@@H](CCC1)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

• Molecular Formula:

  C64H93N19O19

• Molecular Weight:

  1432.54

• References & Citations:

  [1]Zahid M, et al. Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice. PLoS One. 2010 Aug 17;5 (8) :e12252. |[2]Gallicano, G. I., et al., (2022) . Reversing Cardiac Hypertrophy at the Source Using a Cardiac Targeting Peptide Linked to miRNA106a: Targeting Genes That Cause Cardiac Hypertrophy.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [1052692-86-0]