RegisterLogin

CTPI-2

CAT: 0804-HY-123986-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-123986-01Size:100 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a KD of 3.5 μM. CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity[1][2].
CAS Number
[68003-38-3]
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319, H332, H335
Target
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ctpi-2.html
Purity
99.99
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=CC=C1NS(=O)(C2=CC=C(Cl)C([N+]([O-])=O)=C2)=O
Molecular Formula
C13H9ClN2O6S
Molecular Weight
356.74
Precautions
H302, H312, H315, H319, H332, H335
References & Citations
[1]Tan M, et al. Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Cell Death Differ. 2020;27 (7) :2143-2157.|[2]Fernandez HR, et al. The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer. Cell Death Differ. 2018;25 (7) :1239-1258.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-W7845692'-OMe-CTP
HY-1715783′-Amino-2′,3′-dideoxy-CTP
HY-1715743′-Azido-2′,3′-dideoxy-CTP
HY-137649ASp-2'-O-Me-CTPαS (tetrasodium)
HY-137649CRp-2'-O-Me-CTPαS (tetrasodium)
HY-W011060-01Cryptand 2.2.2
HY-B1500-012,2,2-Trichloroethanol
HY-W0733142,2,2-Trifluoroethoxyamine (hydrochloride)
HY-N2048-012,2':5',2''-Terthiophene
HY-B1500R-012,2,2-Trichloroethanol (Standard)

Alternative Products

CatalogName
T8732-01CTPI-2
7794/50CTPI 2
MBS7072460Recombinant Mycobacterium tuberculosis Probable cation-transporting ATPase I (ctpI), partial
MBS1030567-01Recombinant Mycobacterium leprae Probable cation-transporting ATPase I (ctpI), partial
MBS9380932Plant Cross-Linked C-Terminal Telopeptides of Type I Collagen (CTPI) ELISA Kit
PC1003049-012,2,2-Trifluoroethyl 2,2,2-trichloroacetate
H 038-0052'- , 2''-, 2''', 2'''', 2''''', 2''''''- Hexadeoxy- 2'-, 2'', 2''', 2'''', 2''''', 2''''''- hexafluoro- cyclic hexaadenosine monophosphate (2',2'',2''',2'''',2''''',2''''''-Hexa-F-c-hexadAMP / cFA6), sodium salt
PC32719-012,2,2,2'-Tetrafluoroacetophenone
OR1009873-012,2,2,2-Ethylenedinitrilotetraethanol
290342-012,2,2-Trifluoroethyl 2,5-bis (2,2,2-trifluoroethoxy) benzoate

Popular Products