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ASCT2-IN-1

CAT: 0804-HY-163198-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-163198-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ASCT2-IN-1 (compound 20k) is an ASCT2 inhibitor with IC50 values of 5.6 μM and 3.5 μM in cells A549 and HEK293, respectively. ASCT2-IN-1 induces cell apoptosis. ASCT2-IN-1 inhibits tumor growth[1].
CAS Number
3032651-18-3
UNSPSC
12352005
Target
Apoptosis; ASCT; Autophagy; mTOR
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/asct2-in-1.html
Concentration
10mM
Purity
98.21
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N[C@@H](CCN(CC1=C(C=CC=C1)OCC#CC2=CC=C(C=C2)Cl)CC3=CC=CC=C3OCC#CC4=CC=C(C=C4)Cl)C(O)=O
Molecular Formula
C36H32Cl2N2O4
Molecular Weight
627.56
References & Citations
[1]Qin L, et al., Discovery of Novel Aminobutanoic Acid-Based ASCT2 Inhibitors for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2024 Jan 13. doi: 10.1021/acs.jmedchem.3c01093
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ASCT2

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