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ASCT2-IN-2

CAT: 0804-HY-163199-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-163199-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ASCT2-IN-2 (compound 25e) is an ASCT2 inhibitor with IC50 of 5.14 μM. ASCT2-IN-2 regulates amino acid metabolism as well as mTOR signaling and thereby induces cell apoptosis. ASCT2-IN-2 inhibits tumor growth[1].
UNSPSC
12352005
Target
Apoptosis; ASCT; Autophagy; mTOR
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/asct2-in-2.html
Purity
99.10
Solubility
DMSO : ≥ 150 mg/mL
Smiles
N[C@@H](CCN(CC1=C(C=CC(C(C)(C)C)=C1)OCC#CC2=CC=CC=C2)CC3=CC(C(C)(C)C)=CC=C3OCC#CC4=CC=CC=C4)C(O)=O
Molecular Formula
C44H50N2O4
Molecular Weight
670.88
References & Citations
[1]Qin L et al., Discovery of Novel Aminobutanoic Acid-Based ASCT2 Inhibitors for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2024 Jan 13. doi: 10.1021/acs.jmedchem.3c01093
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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