Hupehenine

Hupehenine is an orally active isosteroidal alkaloid that can be extracted from F. hupehensis. Hupehenine exhibits activities such as antitussive, expectorant, anticancer, and antiparasitic. In vitro, Hupehenine can also inhibit α-synuclein seeded fibril formation, making it applicable for the research of Parkinson's disease and other related disorders[1][2][3][4].

98243-57-3

12352005

Apoptosis; Autophagy; Parasite; Reactive Oxygen Species (ROS) ; α-synuclein

Natural Products

Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

COVID-19-immunoregulation

Cancer; Infection; Inflammation/Immunology; Neurological Disease

https://www.medchemexpress.com/hupehenine.html

99.0

DMSO : 100 mg/mL (ultrasonic)

O[C@H]1CC[C@@]2(C)[C@]([C@H](O)C[C@]3([H])[C@]2([H])C[C@]4([H])[C@@]3([H])CC[C@]5([H])[C@@]4([H])CN6[C@](CC[C@H](C)C6)([H])[C@@H]5C)([H])C1

C27H45NO2

415.65

[1]Wu X, et al. Investigation of association of chemical profiles with the tracheobronchial relaxant activity of Chinese medicinal herb Beimu derived from various Fritillaria species. J Ethnopharmacol. 2018 Jan 10;210:39-46.|[2]Xin M, et al. Design, synthesis, and evaluation of pyrrolo[2,1-f][1,2,4]triazine derivatives as novel hedgehog signaling pathway inhibitors. Bioorg Med Chem. 2014 Feb 15;22 (4) :1429-40.|[3]Ghanem SS, et al. Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity. Molecules. 2021 Jun 19;26 (12) :3736.|[4]Wen C, et al. Determination and validation of hupehenine in rat plasma by UPLC-MS/MS and its application to pharmacokinetic study. Biomed Chromatogr. 2015 Dec;29 (12) :1805-10.|[5]Menpadi N, et al. Molecular Mechanisms of Cell Death in Leishmania donovani Induced by Selected Steroidal Alkaloids. J Basic Microbiol. 2025 Mar;65 (3) :e2400655.

Room Temperature

4°C (Powder, protect from light)

Natural Products