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Anti-MAP3K12 Antibody

CAT: 1303-75-355Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1303-75-355Size:100 µL
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Background
Mitogen-activated protein kinase kinase kinase 12, or MAP3K12 is a member of the serine/threonine protein kinase family. MAP3K12 is expressed many tissues including kidney, lung, heart, testis, gastrointestinal tract, stomach, liver and pancreas. In brain, MAP3K12 is mainly expressed in neurons at synaptic terminals. MAP3K12 is thought to initiate signalling cascades which effect the developing mammalian nervous system, including processes such as neuronal migration and axon growth.
Description
Our Anti-MAP3K12 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N377/20. It is KO validated, detects mouse and rat MAP3K12, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
Short Description
Our Anti-MAP3K12 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N377/20. It is KO validated, detects mouse and rat MAP3K12, and is purified by protein a chromatography. It is great for use in WB, IHC, ICC, ELISA.
Synonyms
Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase)
Gene Name
Map3k12 Zpk
UniProt
Q60700
Host
Mouse
Reactivity
Mouse and Rat
Immunogen
Fusion protein amino acids 727-888 (C-terminus) of mouse MAP3K12 (accession number Q60700) produced recombinantly in E. Coli
Target
MAP3K12
Clonality
Monoclonal
Isotype
IgG2a
Clone
N377/20
Type
Primary Antibody
Applications
WB, IHC, ICC, ELISA
Field of Research
Cell Signaling
Concentration
1 mg/mL
Format
Purified by Protein A chromatography
Buffer
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Molecular Weight
120 kDa
Shipping Conditions
Shipped on ice packs
Storage Conditions
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Notes
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
Specificity
Does not cross-react with MAP3K13
Quality Control
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
Recommended Usage
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Physical Properties
Liquid
Immunogen Species
Mouse
WB Brain Quality Control
1
Conjugate
Unconjugated
RRID
AB_2315888

UniProtKB · Q60700

Mitogen-activated protein kinase kinase kinase 12

M3K12_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q60700
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Map3k12
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
2.7.11.25
Processing
—
Secondary accessions
P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6
Protein keywords

Ligand

ATP-bindingMagnesiumNucleotide-binding

Cellular component

Cell membraneCytoplasmMembrane

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

Technical term

Reference proteome

Domain

Repeat

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