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Anti-Complement C5b-9 Antibody

CAT: 1303-DIA 011-01-1Size: 1000 µLDry Ice: NoHazardous: No
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CAT#:1303-DIA 011-01-1Size:1000 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
C5b-9 is also known as the terminal complement complex (TCC) . The TCC consists of C5b, C6, C7, C8 and C9 and forms the membrane attack complex (MAC) as well as the non-lytic fluid-phase SC5b-9 complex (with protein S) . The MAC forms channels in target cell membranes leading to cell lysis by osmotic leakage. The complexes contain neoantigens that are absent from the individual native components from which they are formed and DIA 011-01 is directed against a neoepitope exposed on C9 when incorporated into the TCC.
Description
Our mouse Complement C5b-9 monoclonal antibody from Antibodies Incorporated is produced from clone aE11. It detects horse, human, non-human primate, and pig Complement C5b-9 and is Protein A or Protein G purified. Works in ELISA, IF, IHC, WB.
Synonyms
C5, C5D, C5a, C5b, CPAMD4, ECLZB, complement C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, C5a anaphylatoxin, anaphylatoxin C5a analog, complement component 5, prepro-C5
Gene Name
C5, C6, C7, C8, C9
NCBI Gene ID
727
UniProt
P01031, P13671, P06681, P07357, P07358, P07360, P02749
Host
Mouse
Reactivity
Horse, Human, Non-Human Primate, and Pig
Immunogen
Purified C5b-9
Target
Complement C5b-9
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
AE11
Type
Primary Antibodies
Applications
ELISA, IF, IHC, WB
Concentration
1 mg/mL ±15%
Format
Protein A or Protein G purified
Buffer
0.01 M phosphate buffer, pH 7.4, containing 0.15 M NaCl, 0,09% sodium azide
Shipping Conditions
Shipped on ice packs
Storage Conditions
2-8°C without exposure to light
Notes
BSA free
Specificity
DIA 011-01 binds both membrane-bound MAC (active) and fluid-phase SC5b-9 complexes (inactive) . (1) DIA 011-01 binds to a neoepitope exposed on C9
Brand
Antibodies Inc (via BioPorto acquisition)
Recommended Usage
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Physical Properties
Liquid
Immunogen Species
Human

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