Products for Research Use Only
RegisterLogin

CDK8 ligand 1

CAT: 0804-HY-168683-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-168683-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CDK8 ligand 1 is the ligand of CDK8. CDK8 ligand 1 can be used to synthesize LL-K8-22.
CAS Number
2924557-38-8
UNSPSC
12352005
Target
CDK; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk8-ligand-1.html
Purity
98.0
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(CN1C=C(C2=CC=C(C3=CN=CC4=CC=CC=C43)C=C2)C=N1)N5CCNCC5
Molecular Formula
C24H23N5O
Molecular Weight
397.47
References & Citations
[1]Wang M, et al. Discovery of LL-K8-22: A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex. J Med Chem. 2023 Apr 13;66 (7) :4932-4951.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK8

Chemical Information

2-(4-(4-(Isoquinolin-4-yl)phenyl)-1H-pyrazol-1-yl)-1-(piperazin-1-yl)ethan-1-one
CAS Number2924557-38-8
PubChem CID169783353
IUPAC Name2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]-1-piperazin-1-ylethanone
Molecular FormulaC24H23N5O
Molecular Weight397.5
XLogP2.6
Topological Polar Surface Area63.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count30
Formal Charge0
Complexity572
SMILES
C1CN(CCN1)C(=O)CN2C=C(C=N2)C3=CC=C(C=C3)C4=CN=CC5=CC=CC=C54
InChI
InChI=1S/C24H23N5O/c30-24(28-11-9-25-10-12-28)17-29-16-21(14-27-29)18-5-7-19(8-6-18)23-15-26-13-20-3-1-2-4-22(20)23/h1-8,13-16,25H,9-12,17H2
InChIKey
SQZGEYUMOOLNPI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(4-(4-(Isoquinolin-4-yl)phenyl)-1H-pyrazol-1-yl)-1-(piperazin-1-yl)ethan-1-one
CAS: 2924557-38-8
CID: 169783353
Formula: C24H23N5O
MW: 397.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight397.5
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass397.19026037
Monoisotopic Mass397.19026037
Topological Polar Surface Area63.1 Ų
Heavy Atom Count30
Formal Charge0
Complexity572
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-103492-01CDK8-IN-1
HY-111427-01CDK8/19-IN-1
HY-161829CDK7 ligand 1
HY-115729-01PROTAC CDK9 ligand-1
HY-161709FLT3/CDKs ligand-1
HY-171174-01CDK8-IN-16
HY-111463-01CDK8-IN-3
HY-162600CDK8-IN-15
HY-151463-01CDK8-IN-11
HY-147716CDK8-IN-6

Alternative Products

CatalogName
399096-01CDK8
BA3104-5CDK8-IN-13
BA3810-10CDK8-IN-1
BA3859-1CDK8-IN-12
70R-31732CDK8 antibody
GWB-728817Cdk8, Antibody
534566-01Cdk8 discontinued
501359CDK8, CT
DF2309-BPCDK8 Peptide
464161CDK8/19i

Popular Products