PAD4-IN-2 (TFA)

PAD4-IN-2 (TFA)

• UNSPSC Description: PAD4-IN-2 (compound 5i) TFA is a PAD4 inhibitor (IC50=1.94 μM). PAD4-IN-2 TFA inhibits tumor growth in mice by specifically inhibiting the PAD4-H3cit-NETs pathway in neutrophils[1].
• Target Antigen: Protein Arginine Deiminase
• Type: Reference compound
• Related Pathways: Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pad4-in-2-tfa.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(NCC1=CC=CC(B(O)O)=C1)[C@H](CCCNC(CCl)=N)NC2=CC=C([N+]([O-])=O)C3=NON=C32.O=C(C(F)(F)F)O
• Molecular Weight: 617.73
• References & Citations: [1]Zhu D, et al. Highly-tumor-targeted PAD4 inhibitors with PBA modification inhibit tumors in vivo by specifically inhibiting the PAD4-H3cit-NETs pathway in neutrophils. Eur J Med Chem. 2023 Oct 5;258:115619.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported