Products for Research Use Only
RegisterLogin

Anatabine (dicitrate)

CAT: 0804-HY-19918A-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-19918A-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate is a potent α4β2 nAChR agonist. Anatabine dicitrate inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid precursor protein (APP) . Anatabine dicitrate has anti-inflammatory effects and has the potential for neurodegenerative disorders treatment[1][2][3].
UNSPSC
12352005
Target
Amyloid-β; nAChR; NF-κB
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/anatabine-dicitrate.html
Purity
99.03
Solubility
DMSO : 30 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(CC(C(O)=O)(O)CC(O)=O)O.O=C(CC(C(O)=O)(O)CC(O)=O)O.[C@@H]1(C2=CC=CN=C2)CC=CCN1
Molecular Formula
C22H28N2O14
Molecular Weight
544.46
References & Citations
[1]Paris D, et al. Anatabine lowers Alzheimer's Aβ production in vitro and in vivo. Eur J Pharmacol. 2011 Nov 30;670 (2-3) :384-91.|[2]Xing H, et al. A Pharmacological Comparison of Two Isomeric Nicotinic Receptor Agonists: The Marine Toxin Isoanatabine and the Tobacco Alkaloid Anatabine. Mar Drugs. 2020 Feb 11;18 (2) . pii: E106.|[3]eo EJ, et al. Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer's disease. Pharmacol Res. 2018 Mar;129:262-273.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-13574Biricodar (dicitrate)
HY-126047-01(S) - (-) -Anatabine
HY-126047B-01(R) - (+) -Anatabine
HY-W115798-01Trimagnesium dicitrate nonahydrate, 99%
HY-126047A-01(R, S) -Anatabine
HY-126047AS(R, S) -Anatabine-d4
HY-126047AR-01(R, S) -Anatabine (Standard)
HY-W743379(S) -N-Nitroso anatabine-d4
HY-B1532-01Anabasine
HY-W052144-01(±) Anabasine

Alternative Products

CatalogName
T10318-01Anatabine dicitrate
ZGA25413-01Biricodar dicitrate (vx-710 dicitrate)
A13533-100Biricodar dicitrate (VX-710 dicitrate) 100mg
IN11919-01Trimagnesium Dicitrate
GTR19211850-01Biricodar dicitrate
TBP04427Anatabine
A13533-1Biricodar dicitrate (VX-710 dicitrate) 1mg
A13533-50Biricodar dicitrate (VX-710 dicitrate) 50mg
A13533-5Biricodar dicitrate 5mg
GTR19209113-01APD-916 dicitrate

Popular Products