FAUC 365

• Description :

  FAUC 365 is a highly dopamine D3 receptor-selective antagonist with Ki values of 0.5 nM, 340, 2600, and 3600 nM at D3, D4.4, D2short, and D2Long receptors, respectively. FAUC 365 can be used for the research of schizophrenia, and Parkinson's disease[1][2].

• UNSPSC :

  12352005

• Target :

  Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/fauc-365.html

• Concentration :

  10mM

• Purity :

  98.75

• Solubility :

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles :

  ClC1=C(C(N2CCN(CC2)CCCCNC(C3=CC4=C(S3)C=CC=C4)=O)=CC=C1)Cl

• Molecular Formula :

  C23H25Cl2N3OS

• Molecular Weight :

  462.44

• References & Citations :

  [1]Philip Seeman, et al. Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus. Synapse. 2006 Sep 1;60 (3) :205-11.|[2]Carsten Hocke, et al. Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype. Bioorg Med Chem Lett. 2004 Aug 2;14 (15) :3963-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [474432-66-1]