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8-Hydroxyefavirenz

CAT: 0804-HY-137397-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137397-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of. 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer[1]. 8-Hydroxyefavirenz is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
205754-33-2
Product Name Alternative
8-OH-EFV
UNSPSC
12352005
Hazard Statement
H302-H360-H410
Target
Apoptosis; JNK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8-hydroxyefavirenz.html
Purity
98.0
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(O)C=C(Cl)C=C2[C@](C(F)(F)F)(C#CC3CC3)O1
Molecular Formula
C14H9ClF3NO3
Molecular Weight
331.67
Precautions
P264-P270-P273-P280-P330-P391-P405-P501
References & Citations
[1]Bumpus NN. Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. Toxicol Appl Pharmacol. 2011 Dec 1;257 (2) :227-34.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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