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Amentoflavone (Standard)

CAT: 0804-HY-N0662R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0662R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA (A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase[1][2][3][4].
CAS Number
1617-53-4
Product Name Alternative
Didemethyl-ginkgetin (Standard)
UNSPSC
12352005
Target
Apoptosis; Bacterial; Fungal; GABA Receptor; Reactive Oxygen Species (ROS) ; Reference Standards; RSV
Type
Reference Standards
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/amentoflavone-standard.html
Smiles
O=C1C=C(C2=CC=C(O)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4O)C(O)=CC(O)=C13
Molecular Formula
C30H18O10
Molecular Weight
538.46
References & Citations
[1]Zhang Z, et al. Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects. Neural Regen Res. 2015 Jul;10 (7) :1125-33. |[2]Woo ER, et al. Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB activation in macrophages. Pharmacol Res. 2005 Jun;51 (6) :539-46.|[3]Woo ER, et al. Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB activation in macrophages. Pharmacol Res. 2005 Jun;51 (6) :539-46.|[4]Yen TH, et al. Amentoflavone Induces Apoptosis and Inhibits NF-ĸB-modulated Anti-apoptotic Signaling in Glioblastoma Cells. In Vivo. 2018 Mar-Apr;32 (2) :279-285.|[5]Hwang JH, et al. Antibacterial effect of amentoflavone and its synergistic effect with antibiotics. J Microbiol Biotechnol. 2013;23 (7) :953-8.|[6]Hanrahan JR, et al. Semisynthetic preparation of amentoflavone: A negative modulator at GABA (A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13 (14) :2281-4.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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