Amentoflavone

• Description:

  Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA (A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase[1][2][3][4].

• Product Name Alternative:

  Didemethyl-ginkgetin

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; Bacterial; Fungal; GABA Receptor; Reactive Oxygen Species (ROS) ; RSV

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Amentoflavone.html

• Concentration:

  10mM

• Purity:

  99.66

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1C=C (C2=CC=C (O) C=C2) OC3=C (C4=CC (C5=CC (C6=C (O) C=C (O) C=C6O5) =O) =CC=C4O) C (O) =CC (O) =C13

• Molecular Formula:

  C30H18O10

• Molecular Weight:

  538.46

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Zhang Z, et al. Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects. Neural Regen Res. 2015 Jul;10 (7) :1125-33. |[2]Woo ER, et al. Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB activation in macrophages. Pharmacol Res. 2005 Jun;51 (6) :539-46.|[3]Woo ER, et al. Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB activation in macrophages. Pharmacol Res. 2005 Jun;51 (6) :539-46.|[4]Yen TH, et al. Amentoflavone Induces Apoptosis and Inhibits NF-ĸB-modulated Anti-apoptotic Signaling in Glioblastoma Cells. In Vivo. 2018 Mar-Apr;32 (2) :279-285.|[5]Hwang JH, et al. Antibacterial effect of amentoflavone and its synergistic effect with antibiotics. J Microbiol Biotechnol. 2013;23 (7) :953-8.|[6]Hanrahan JR, et al. Semisynthetic preparation of amentoflavone: A negative modulator at GABA (A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13 (14) :2281-4.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  1617-53-4