MTEP (hydrochloride)

MTEP (hydrochloride)

• CAS Number: 1186195-60-7
• UNSPSC Description: MTEP hydrochloride is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC50 of 5 nM and a Ki of 16 nM. MTEP hydrochloride shows antidepressant and anxiolytic-like effects. MTEP hydrochloride can be used for Parkinson's disease research[1][2][3][4].
• Target Antigen: mGluR
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/MTEP-hydrochloride.html
• Purity: 99.81
• Solubility: H2O : 20 mg/mL (ultrasonic)
• Smiles: CC1=NC(C#CC2=CC=CN=C2)=CS1.[H]Cl
• Molecular Weight: 236.72
• References & Citations: [1]Lea PM 4th, et al. Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev. 2006 Summer;12(2):149-66.|[2]Ossowska K, et al. MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats. Neuropharmacology. 2005 Sep;49(4):447-55.|[3]Pałucha A, et al. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacol Biochem Behav. 2005 Aug;81(4):901-6.|[4]Klodzinska A, et al. Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling. Neuropharmacology. 2004 Sep;47(3):342-50.Neurochem Int. 2024 Jun 4:178:105786.|Sci Adv. 2022 Aug 19;8(33):eabn7357.|Psychopharmacology. 2024 Mar 9.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported