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MTEP (hydrochloride)

CAT: 0804-HY-13206-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13206-01Size:5 mg
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Description
MTEP hydrochloride is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC50 of 5 nM and a Ki of 16 nM. MTEP hydrochloride shows antidepressant and anxiolytic-like effects. MTEP hydrochloride can be used for Parkinson's disease research[1][2][3][4].
CAS Number
1186195-60-7
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/MTEP-hydrochloride.html
Concentration
10mM
Purity
99.79
Solubility
H2O : 20 mg/mL (ultrasonic)
Smiles
CC1=NC(C#CC2=CC=CN=C2)=CS1.[H]Cl
Molecular Formula
C11H9ClN2S
Molecular Weight
236.72
References & Citations
[1]Lea PM 4th, et al. Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev. 2006 Summer;12 (2) :149-66.|[2]Ossowska K, et al. MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats. Neuropharmacology. 2005 Sep;49 (4) :447-55.|[3]Pałucha A, et al. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacol Biochem Behav. 2005 Aug;81 (4) :901-6.|[4]Klodzinska A, et al. Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA (A) signaling. Neuropharmacology. 2004 Sep;47 (3) :342-50.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
Citation 01
Neurochem Int. 2024 Jun 4:178:105786.|Sci Adv. 2022 Aug 19;8 (33) :eabn7357.|Psychopharmacology (Berl) . 2024 Jul;241 (7) :1399-1415.

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