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MTEP

CAT: 0804-HY-13206A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13206A-01Size:5 mg
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Description
MTEP is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC50 of 5 nM and a Ki of 16 nM. MTEP shows antidepressant and anxiolytic-like effects. MTEP can be used for Parkinson's disease research[1][2][3][4]. MTEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
329205-68-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mtep.html
Purity
99.91
Solubility
10 mM in DMSO
Smiles
CC1=NC(C#CC2=CC=CN=C2)=CS1
Molecular Formula
C11H8N2S
Molecular Weight
200.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Lea PM 4th, et al. Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev. 2006 Summer;12 (2) :149-66.|[2]Ossowska K, et al. MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats. Neuropharmacology. 2005 Sep;49 (4) :447-55.|[3]Klodzinska A, et al. Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA (A) signaling. Neuropharmacology. 2004 Sep;47 (3) :342-50.|[4]Pałucha A, et al. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacol Biochem Behav. 2005 Aug;81 (4) :901-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
Citation 01
Psychopharmacology (Berl) . 2024 Jul;241 (7) :1399-1415.|Neurochem Int. 2024 Jun 4:178:105786.|Sci Adv. 2022 Aug 19;8 (33) :eabn7357.

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