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(±) -Vesamicol (hydrochloride)

CAT: 0804-HY-B1813A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1813A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(±) -Vesamicol hydrochloride ((±) -AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. (±) -Vesamicol hydrochloride also displays high affinity for σ1 and σ2 receptors with Kis of 26 nM and 34 nM, respectively[1][2].
CAS Number
120447-62-3
Product Name Alternative
(±) -AH5183 (hydrochloride)
UNSPSC
12352005
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/racemic-vesamicol-hydrochloride.html
Purity
99.81
Solubility
DMSO : 14 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@H]1[C@H](N2CCC(C3=CC=CC=C3)CC2)CCCC1.[H]Cl
Molecular Formula
C17H26ClNO
Molecular Weight
295.85
References & Citations
[1]S M Efange, et al. N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters. J Med Chem. 1997 Nov 21;40 (24) :3905-14.|[2]H Kobayashi, et al. Effects of systemic administration of 2- (4-phenyl-piperidino) -cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats. Brain Res Bull. 1997;43 (1) :17-23.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Sigma 1 Receptor; Sigma 2 Receptor

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