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Maprotiline (hydrochloride)

CAT: 0804-HY-B0444-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0444-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Maprotiline hydrochloride is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects with oral activity. Maprotiline hydrochloride induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1[1][2].
CAS Number
10347-81-6
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Autophagy; ERK
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/maprotiline-hydrochloride.html
Purity
99.98
Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 2.2 mg/mL (ultrasonic)
Smiles
CNCCCC1(CC2)C3=CC=CC=C3C2C4=CC=CC=C14.Cl
Molecular Formula
C20H24ClN
Molecular Weight
313.86
Precautions
H302
References & Citations
[1]Zheng C, et al. Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1. Front Pharmacol. 2021 May 20. 12:689767.|[2]Gunduz O, et al. Analysis of the anti-allodynic effects of combination of a synthetic cannabinoid and a selective noradrenaline re-uptake inhibitor in nerve injury-induced neuropathic mice. Eur J Pain. 2016 Mar. 20 (3) :465-71.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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