Maprotiline

• UNSPSC Description:

  Maprotiline is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1[1][2].

• Target Antigen:

  Apoptosis; Autophagy; ERK

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;MAPK/ERK Pathway;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/maprotiline.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CNCCCC12C3=C(C=CC=C3)C(CC2)C4=CC=CC=C14

• Molecular Weight:

  277.40

• References & Citations:

  [1]Gunduz O, et al. Analysis of the anti-allodynic effects of combination of a synthetic cannabinoid and a selective noradrenaline re-uptake inhibitor in nerve injury-induced neuropathic mice. Eur J Pain. 2016 Mar. 20(3):465-71.|[2]Zheng C, et al. Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1. Front Pharmacol. 2021 May 20. 12:689767.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  10262-69-8