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Maprotiline

CAT: 0804-HY-B0444ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0444ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Maprotiline is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1[1][2].
CAS Number
10262-69-8
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Apoptosis; Autophagy; ERK
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/maprotiline.html
Solubility
10 mM in DMSO
Smiles
CNCCCC12C3=C(C=CC=C3)C(CC2)C4=CC=CC=C14
Molecular Formula
C20H23N
Molecular Weight
277.40
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Gunduz O, et al. Analysis of the anti-allodynic effects of combination of a synthetic cannabinoid and a selective noradrenaline re-uptake inhibitor in nerve injury-induced neuropathic mice. Eur J Pain. 2016 Mar. 20 (3) :465-71.|[2]Zheng C, et al. Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1. Front Pharmacol. 2021 May 20. 12:689767.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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